Biography

Caroline Demily studied medicine in Amiens and did her psychiatry internship in Rouen. She has been working in Lyon since 2006, first as chief resident, then as hospital practitioner.

Her efforts in the study of genetic conditions associated with cognitive and psychiatric disorders enabled the ARS Rhône-Alpes to run a regional center for screening and treating psychiatric disorders caused by genetic factors since January 2013. This center screens for rare genetic conditions in children and adults with unusual mental disorders and designs assessment and stimulation therapy strategies (cognitive training) if a rare condition has been diagnosed. A strong partnership with the Genetics Department at Hospices Civils de Lyon has been initiated to develop this innovating approach (Prof Patrick Edery and Prof Damien Sanlaville).

With a financial support from the AFRC and in collaboration with SBT, the center’s team elaborated a new cognitive remediation program for children: “Cognitus et moi” (Cognitus and me). This program targets attention and visuospatial processes, which are deeply involved in social cognition.

Bibliography

International publications

Leleu A, Saucourt G, Rigard C, Baudouin JY, Rossi M, Edery P, Franck N, Demily C. Emotional face space in children and adolescents with 22q11.2 deletion syndrome. Eur Child Adolesc Psychiatry 2015

Pillet B, Morvan Y, Todd A, Franck N, Duboc C, Grosz A, Launay C, Demily C, Gaillard R, Krebs MO, Amado I. Cognitive Remediation Therapy (CRT) benefits more to patients with schizophrenia with low initial memory performances. Disability and Rehabilitation 2015; 37, 846-853

Demily C, Rossi M, Chesnoy-Servanin G, Martin B, Poisson A, Sanlaville D, Edery P. Complex phenotype with social communication disorder caused by mosaic supernumerary ring chromosome 19p. BMC Med Genet. 2014; 15: 132.

Demily C, Sedel F.Psychiatric manifestations of treatable hereditary metabolic disorders in adults. Ann Gen Psychiatry. 2014; 13:27.

Franck N., Duboc C., Sundby C., Amado I., Wykes T., Demily C., Launay C., Le Roy V., Bloch P., Willard D., Todd A., Petitjean F., Foullu S., Briant P., Grillon M.L., Deppen P., Verdoux H., Bralet M.C., Januel D., Roy P., all the other members of the Cognitive Remediation Network, Vianin P. Specific vs general cognitive remediation for executive functioning in schizophrenia: a multicenter randomized trial. Schizophrenia Research 2013;147 68-74

Bruno N, Sachs N, Demily C, Franck N, Pacherie E. Delusions and metacognition in patients with schizophrenia. Cogn Neuropsychiatry 2012; 17: 1-18.

Demily C, Weiss T, Chambon V, Baudouin JY, Franck N. Self-generated facial emotions recognition is impaired in schizophrenia. J Neuropsychiatry Clin Neurosci 2011; 23: 189-193.

Demily C, Attala N, Fouldrin G, Czernecki V, Ménard JF, Lamy S, Dubois B, Thibaut F. The Emotional Stroop task: A comparison between schizophrenic subjects and controls. Eur Psychiatry 2010; 25: 75-79.

Demily C, Cavézian C, Desmurget M, Berquand-Merle M, Chambon V, Franck N. The game of chess enhances cognitive abilities in schizophrenia. Schizophr Res 2009; 107: 112-113.

Legallic S, Bou J, Haouzir S, Allio G, Demily C, Petit M, Frebourg T, Thibaut F, Campion D. No pathogenic rearrangement of the DISC1 gene in psychosis. Am J Med Genet B Neuropsychiatr Genet 2009; 150B: 148-50.

Demily C, Franck N. Cognitive remediation: a promising tool for treatment of schizophrenia. Exp Rev Neurother 2008; 8: 1029-36.

Demily C, Franck N. Gabapentin for ultra resistant schizophrenia with aggressive behavior. Schizophr Res. 2008; 100: 349-50

Demily C, Jasse L, Bailly G, Franck N. Chess playing potentiates mental resources in schizophrenia. British Journal of Psychiatry, publication 28/03/2007.

Demily C, Bumsel E, Legallic S, Bou J, van Amelsvoort T, Zinkstok J, Manouvrier-Hanu S, Vogels A, Drouin-Garraud V, Philip N, Philippe A, Heron D, Sarda P, Hannequin D, Petit M, Thibaut F, Frebourg T, Campion D. ZDHHC8 single nucleotidic polymorphism is not associated with psychiatric features of the 22q11 deletion syndrome and schizophrenia. Psychiatric Genetics 2007; 17: 311-312.

Raux G, Bumsel E, Hecketsweiler B, van Amelsvoort T, Zinkstok J, Manouvrier-Hanu S, Fantini C, GM Brévière, Di Rosa G, Pustorino G, Vogels A, Swillen A, Legallic S, Bou J, Opolczynski G, Drouin-Garraud V, Lemarchand M, Philip N, Gérard-Desplanches A, Carlier M, A, Nolen MC, Heron D, Afenjar A, Sarda P, Lacombe D, Coizet C, Alembik Y, Layet V, Hannequin D, Demily C, Petit M, Thibaut F, Frebourg T, Campion D. Involvement of hyperprolinemia in cognititive and psychiatric features of the 22q11 deletion syndrome. Human Molecular Genetics 2007; 16: 83-91.

Guillin O, Demily C, Thibaut F. Brain-derived neurotrophic factor in schizophrenia and its relation with dopamine. Int Rev Neurobiol 2007; 78: 377-395.

Jacquet H* , Demily C*, Houy E , Hecketsweiler B , Bou J , Raux G , Lerond J , Allio G , Haouzir S , Tillaux A , Bellegou C , Fouldrin G , Delamilieure P , Dollfus S , d’Amato T , Petit M , Thibaut F , Frébourg T , Campion D. Hyperprolinemia is a risk factor for schizo-affective disorders. Molecular Psychiatry 2005; 10: 479-485. *: premiers auteurs associés

Peuskens J , Demily C , Thibaut F. Treatment of cognitive dysfunction in schizophrenia. Clinical Therapeutics 2005; 27: 25-37.

Houy E , Raux G , Thibaut F , Belmont A , Demily C , Allio G , Haouzir S , Fouldrin G , Petit M , Frebourg T , Campion D. The promoter –194 C polymorphism of the alpha 7 nicotinic receptor has a protective effect against the P50 sensory gating deficit. Molecular Psychiatry 2004; 9: 320-322.

Jacquet H , Raux G, Thibaut F, Hecketsweiler B , Houy E , Demily C , Haouzir S , Allio G , Fouldrin G , Drouin V , Bou J , Petit M , Campion D , Frébourg T. PRODH mutations and hyperprolinemia in a subset of schizophrenic patients. Human Molecular Genetics 2002; 11: 2243-2249.

Publications in French

Demily C, Rossi M, Schneider M, Edery P, Leleu A, d’Amato T, Franck N, Eliez S. Prise en charge neurocognitive et psychiatrique des patients adultes porteurs de la microdélétion 22q11.2. L’Encéphale 2015; 41: 266-273

Poisson A, Nicolas A, Sanlaville D, Cochat P, De Leersnyder H, Rigard C, Franco P, des Portes V, Edery P, Demily C. Le syndrome de Smit-Magenis, une association unique de troubles du comportement et du cycle veille/sommeil. Arch Pediatr. 2015; 22: 638-45.

Demily C, Chouinard G, Chouinard VA. Comment reconnaître les symptômes psychiatriques liés aux antipsychotiques ? L’Encéphale 2010; 36: 417-424.

Demily C, Franck N. Place du trouble schizo-affectif dans la nosographie actuelle. Annales Médico Psychologiques 2009; 157: 256-263

Demily C, Jacquet P, Marie-Cardine Michel. L’évaluation cognitive permet-elle de distinguer la schizophrénie du trouble bipolaire? L’Encéphale 2009; 35: 139-45.

Weiss T, Baudouin JY, Demily C. Production d’émotions faciales dans la schizophrénie. L’Evolution Psychiatrique 2009; 74: 137-144

Demily C, Thibaut F. Facteurs environnementaux de la schizophrénie. Annales Médico- Psychologique 2007; 166 606-611.

Demily C, Thibaut F. Critères de guérison d’un état dépressif majeur. Encéphale 2005; Décembre : S8-S13.

Demily C , Thibaut F. L’outil génétique permet-il de différencier la schizophrénie de la psychose maniaco-dépressive ? L’Encéphale 2005; XXXI: 23-27, cahier 2.

Educational articles

Demily C, Sedel F. Manifestations psychiatriques des maladies héréditaires du métabolisme. EMC, 2013.

Demily C, Franck N. Le trouble schizo-affectif. EMC, 2010.

Demily C, Franck N. Remédiation cognitive de la schizophrénie. Encyclopédie Médico-chirurgicale. Janvier 2008.

Demily C. Génétique de la schizophrénie. Revue française de psychologie médicale, 2010

Danion C, Domenech P, Demily C, Franck N. Symptômes psychotiques dans les affections médicales générales de l’adulte. Encyclopédie Médico-Chirurgicale. Octobre 2007.

Demily C, Thibaut F. Facteurs étiopathogéniques de la schizophrénie. Formation Médicale Continue, La lettre du psychiatre 2007.

Demily C, Thibaut F. Vulnérabilité génétique à la schizophrénie. La lettre du psychiatre 2005; 1: 15-19.

Demily C , Thibaut F. Aripiprazole: revue des essais cliniques. La lettre du pharmacologue 2005; 19: 15-22.

Demily C , Thibaut F. Schizophrénies et troubles bipolaires: vers un continuum? Interpsy, 2004; 2: 29-30.

• The following article by Isohanni et al. is translated into French to be published in the journal PSN: Predictors and consequences of schizophrenia in the Northern Finland 1966 birth cohort. PSN 2005 ; 3 (Suppl 1) : 8-15.

Books

Franck N., Rengade C.E., Demily C. Psychiatrie, Collection ECN Med, Editions Pradel, Wolters Kluwer France, Rueil-Malmaison, 2009, 145 pp.

Franck N., Rengade, C.E., Demily C. Psychiatrie, 2e édition, Collection ECN Med, Editions Pradel, Wolters Kluwer France, Rueil-Malmaison, 2012, 132 pp.

Demily C, Franck N. Schizophrénie: diagnostic et prise en charge. Elsevier-Masson, Paris, 2013, 200 pp.

Book chapters

Demily C. Remédiation cognitive et 22q11DS. Remédiation cognitive édition coordonnée par le Pr FRANCK, éditions Elsevier Masson, 2012.

Demily C, Thibaut F. Facteurs étiopathogéniques de la schizophrénie. Manuel de psychiatrie, édition coordonnée par le Pr GUELFI et le Pr ROUILLON, Masson. Paris, 2007, révision en 2011.

Demily C, Thibaut F. Les addictions sexuelles. Traité d’addictologie, édition coordonnée par le Pr Reynaud. Médecine Science Flammarion. Paris, 2007.